Actin is an abundant cytoskeletal protein found in all mammalian cells. Six distinct actin isotypes have been identified in mammalian cells. Each is encoded by a separated gene and is expressed in a developmentally regulated and tissue-specific manner. α and β-cytoplasmic actins are expressed in a wide variety of cells. Whereas, expression of α-skeletal, α-cardiac, α-vascular and γ-enteric actins are more restricted to specialized muscle cell type. Actin"s filaments form part of the cytoskeleton and play essential roles in regulating cell shape and movement.
Pathway
Adherens junction; Bacterial invasion of epithelial cells; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Chaperonin-mediated protein folding; Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding; Focal Adhesion; Dilated cardiomyopathy; Folding of actin by CCT/TriC; Gastric acid secretion; Hypertrophic cardiomyopathy (HCM); Influenza A; Leukocyte transendothelial migration; Metabolism of proteins; Myometrial Relaxation and Contraction Pathways; Pathogenic Escherichia coli
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