Anti-B4GALT7 monoclonal antibody, clone AB68323

Antibody Isotype

IgG

Clone

AB68323

Species Reactivity

Human

Immunogen

Full length B4GALT7 protein (Human)

Conjugate

Application Notes

WB: 1/500 - 1/1000;

Alternative Names

B4GALT7; xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I); beta-1,4-galactosyltransferase 7; beta4Gal T7; XGALT 1; B4GAL T7; Beta 1,4 galactosyltransferase 7; Beta 1,4 GalTase 7; Beta4Gal T7; UDP Gal:beta GlcNAc beta

Entrez Gene ID

UniProt ID

Antigen Description

This gene is a member of the beta-1,4-galactosyltransferase (beta4GalT) family. Family members encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose. Each beta4GalT member has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus which then remains uncleaved to function as a transmembrane anchor. The enzyme encoded by this gene attaches the first galactose in the common carbohydrate-protein linkage (GlcA-beta1,3-Gal-beta1,3-Gal-beta1,4-Xyl-beta1-O-Ser) found in proteoglycans. This enzyme differs from other beta4GalTs because it lacks the conserved Cys residues found in beta4GalT1-beta4GalT6 and it is located in cis-Golgi instead of trans-Golgi. Mutations in this gene have been associated with the progeroid form of Ehlers-Danlos syndrome.

Pathway

Glycosaminoglycan biosynthesis - chondroitin sulfate, organism-specific biosystem; Glycosaminoglycan biosynthesis - chondroitin sulfate, conserved biosystem; Glycosaminoglycan biosynthesis - heparan sulfate, organism-specific biosystem; Glycosaminoglycan biosynthesis - heparan sulfate, conserved biosystem; Glycosaminoglycan biosynthesis, linkage tetrasaccharide, organism-specific biosystem; Glycosaminoglycan biosynthesis, linkage tetrasaccharide, conserved biosystem; Metabolic pathways, organism.