Specifications
Immunogen
Synthetic peptide: (C)WRKRQPR(R/L)EERKAPESQED(NH2), corresponding to amino acids 362-380 of Rat RAGE
Target
Alternative Names
AGER; advanced glycosylation end product-specific receptor; RAGE; Advanced glycosylation end product specific receptor; Advanced glycosylation end product-specific receptor; AGER; EC 2.7.11.22; LE 9211 A antigen; LE-9211-A antigen; MAPK MAK MRK overlappin
Product Background
Antigen Description
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimers disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847).
Pathway
Activated TLR4 signalling, organism-specific biosystem; Advanced glycosylation endproduct receptor signaling, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; MyD88 cascade initiated on plasma membrane, organism-specific biosystem; MyD88 dependent cascade initiated on endosome, organism-specific biosystem; MyD88-independent cascade initiated on plasma membrane, organism-specific biosystem; MyD88:Mal cascade initiated on p
Citations
Publication ()
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COA
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