E2 protein; Envelope glycoprotein E2; Gp68; Gp70; HCV E2; HCV envelope glycoprotein E2; Hepatitis C virus envelope glycoprotein E2; Hepatitis C Virus E2; Flaviviridae; Hepacivirus; Hepatitis C virus; NS1
Product Background
Antigen Description
Hepatitis C E2 is a virus envelope glycoprotein which forms a heterodimer with the E1 protein. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells.
Citations
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Q: May I inquire if sodium azide is present in the buffer of Anti-Hepatitis C Virus E2 Antibody?
A: The buffer of Anti-Hepatitis C Virus E2 Antibody contains 0.1% Sodium Azide.
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