HUWE1 (NP_113584, 4281 a.a. ~ 4374 a.a) partial recombinant protein with GST tag. The sequence is FWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHT CFNQLDLPAYESFEKLRHMLLLAIQECSEGFGLA
Conjugate
Unconjugated
Target
Alternative Names
HUWE1; HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase; MULE; Ib772; LASU1; UREB1; HECTH9; URE-B1; ARF-BP1; HSPC272; E3 ubiquitin-protein ligase HUWE1; ARF-binding protein 1; URE-binding protein 1; BJ-HCC-24 tumor antigen; large structu
This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation.
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