Anti-Human HTR5A Polyclonal Antibody (DPABH-02373)

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Synthesized peptide derived from human SR-5A (N-terminal)
Conjugate
Unconjugated

Applications


Application Notes
Recommended dilution:
WB: 1:500-1:2000
IF: 1:200-1:1000
ELISA: 1:10000
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
HTR5A; 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled; 5-HT5A; 5-hydroxytryptamine receptor 5A; 5-HT-5; 5-HT-5A
Entrez Gene ID
UniProt ID

Product Background


Gene summary
HTR5A (5-Hydroxytryptamine Receptor 5A) is a Protein Coding gene. Diseases associated with HTR5A include autistic disorder. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled serotonin receptor activity. An important paralog of this gene is HTR1F. The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization.
Antigen Description
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins. 5-Hydroxytryptamine (serotonin) receptor 5A, also known as HTR5A, is a protein that in humans is encoded by the HTR5A gene. The gene described in this record is a member of 5-hydroxytryptamine receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G proteins, negatively influencing cAMP levels via Gi and Go. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. The 5-HT5A receptor has been shown to be functional in a native expression system.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Francken, BJB; Jurzak, M; et al. The human 5-ht(5A) receptor couples to G(i)/G(o) proteins and inhibits adenylate cyclase in HEK 293 cells. EUROPEAN JOURNAL OF PHARMACOLOGY 361:299-309(1998).
Weiss, HM; Haase, W; et al. Comparative biochemical and pharmacological characterization of the mouse 5HT(5A) 5-hydroxytryptamine receptor and the human beta(2)-adrenergic receptor produced in the methylotrophic yeast Pichia pastoris. BIOCHEMICAL JOURNAL 330:1137-1147(1998).

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