Rabbit Anti-Human HTR2C (C-terminal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to residues near the C terminal of human 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled

Conjugate

Application Notes

WB: 1:200-1:1000

General Notes

This product (Catalog No. DPABH-26944) is a rabbit-derived IgG polyclonal antibody raised against human HTR2C. It has been affinity purified by protein A. This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants.
DPABH-26944 is suitable for use in Western blot (WB) (1:200–1:1,000) application.
DPABH-26944 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

HTR1C; 5-HT2C; 5HTR2C; 5-HTR2C

Entrez Gene ID

UniProt ID