Anti-HMGCS2 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat; Human

Immunogen

A synthetic peptide of human HMGCS2 is used for rabbit immunization.

Conjugate

Alternative Names

HMGCS2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); 3 hydroxy 3 methylglutaryl Coenzyme A synthase 2 (mitochondrial); hydroxymethylglutaryl-CoA synthase, mitochondrial; HMG-CoA synthase; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mit

Entrez Gene ID

UniProt ID

Antigen Description

Mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase (HMGCS2; EC 2.3.3.10) mediates the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for brain, heart, kidney, and other organs during times of carbohydrate deprivation such as fasting (Robinson and Williamson, 1980 [PubMed 6986618]). Also see cytoplasmic HMG-CoA synthase (HMGCS1; MIM 142940), which mediates an early step in cholesterol synthesis.

Pathway

Butanoate metabolism, organism-specific biosystem; Butanoate metabolism, conserved biosystem; C5 isoprenoid biosynthesis, mevalonate pathway, organism-specific biosystem; C5 isoprenoid biosynthesis, mevalonate pathway, conserved biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Ketone body metabolism, organism-specific biosystem; Metabolic pathways, organism-specific biosystem;