Anti-HMGCR (internal region) polyclonal antibody

Species Reactivity

Human

Immunogen

A synthetic peptide corresponding to amino acids at internal region of human HMGCR. The sequence is C-ADPSPQNSTADTSK

Conjugate

Application Notes

ELISA: 1:8000. & The optimal working dilution should be determined by the end user.

Alternative Names

HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase; LDLCQ3; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; HMG-CoA reductase; hydroxymethylglutaryl-CoA reductase; 3-hydroxy-3-methylglutaryl CoA reductase (NADPH);

Entrez Gene ID

UniProt ID

Antigen Description

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Pathway

AMPK signaling; AMPK signaling pathway; Bile secretion; C5 isoprenoid biosynthesis, mevalonate pathway