Specifications
Species Reactivity
Cow; Human
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 50 to the C-terminus of Human Histone H4.
Applications
Application Notes
Flow Cyt: 1μg/106 cells; IHC-P: 0.05 - 1 μg/ml; WB: 1 μg/ml; ChIP: 5 μg/25 μg chromatin; ICC/IF: 5 μg/ml.
Target
Alternative Names
dJ160A22.1; dJ160A22.2; dJ221C16.1; dJ221C16.9; FO108; H4; H4.k; H4/a; H4/b; H4/c
Product Background
Antigen Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Pathway
Amyloids, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Chromosome Maintenance, organism-specific biosystem; Deposition of New CENPA-containing Nucleosomes at the Centromere, organism-specific biosystem; Disease, organism-specific biosystem; Gene Expression, organism-specific biosystem; Meiosis, organism-specific biosystem;
Citations
Publication ()
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COA
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