Specifications
Species Reactivity
Mouse; Rat; Cow; Human
Immunogen
Synthetic peptide corresponding to Human Histone H4 aa 50 to the C-terminus. Synthetic peptide conjugated to KLH derived from within residues 50 to the C-terminus of Human Histone H4.
Applications
Application Notes
IHC-P: 1 μg/ml; ChIP: 5 μg/25 μg chromatin; WB: 1 μg/ml; ICC/IF: 5 μg/ml.
Target
Alternative Names
HIST4H4; histone cluster 4, H4; histone 4, H4; histone H4; MGC24116; H4/p; HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; HIST2H4A; HIST2H4B;
Product Background
Antigen Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Pathway
Amyloids, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Chromosome Maintenance, organism-specific biosystem; Deposition of New CENPA-containing Nucleosomes at the Centromere, organism-specific biosystem; Disease, organism-specific biosystem; Gene Expression, organism-specific biosystem; Meiosis, organism-specific biosystem;
Citations
Publication ()
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COA
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