Anti-HIST1H4D monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human HIST1H4D is used for rabbit immunization.

Conjugate

Alternative Names

HIST1H4D; histone cluster 1, H4d; H4/b; H4FB; dJ221C16.9; histone H4; histone 1, H4d; H4 histone family, member B;

Entrez Gene ID

UniProt ID

Antigen Description

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

Pathway

Alcoholism; Amyloids; Cell Cycle; Cell Cycle, Mitotic; Cellular Senescence; Cellular responses to stress; Chromatin modifying enzymes; Chromatin organization; Chromosome Maintenance; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence.