Specifications
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S28 of human HIST1H3B.
Applications
Application Notes
ELISA: 1:1000; WB: 1:100-500.; The optimal working dilution should be determined by the end user.
Target
Alternative Names
HIST1H3B; histone cluster 1, H3b; H3/l; H3FL; histone H3.1; histone H3/l; histone 1, H3b; H3 histone family, member L;
Product Background
Antigen Description
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.
Pathway
Alcoholism; Amyloids; Cell Cycle, Mitotic; Cellular responses to stress.
Citations
Publication ()
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COA
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