Synthetic peptide within Human Histone H2B.1 aa 1-30 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: P62807
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. The H2B.1 gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
Pathway
Alcoholism; Amyloids; Cell Cycle, Mitotic; Cellular responses to stress
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Citations
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Sanders, AR; Goring, HHH; et al. Transcriptome study of differential expression in schizophrenia. HUMAN MOLECULAR GENETICS 22:5001-5014(2013).
Wu, RSC; Wu, KC; et al. Etomidate Induces Cytotoxic Effects and Gene Expression in a Murine Leukemia Macrophage Cell Line (RAW264.7). ANTICANCER RESEARCH 31:2203-2208(2011).
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