Anti-HAVCR2 monoclonal antibody, clone G49-3F3 [Brilliant Violet 421]

Antibody Isotype

IgG1

Clone

G49-3F3

Species Reactivity

Human; Rhesus monkey

Immunogen

Human Tim-3 fusion protein

Conjugate

Application Notes

For immunofluorescent staining, the suggested use of this reagent is ≤5 μl per million cells or 5 μl per 100 μl of whole blood.

Alternative Names

HAVCR2; hepatitis A virus cellular receptor 2; FLJ14428; Tim 3; TIM3; TIMD3; kidney injury molecule-3; T-cell membrane protein 3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain-containing protein 3; KI

Entrez Gene ID

UniProt ID

Antigen Description

Tim-3 is a transmembrane protein also known as T cell immunoglobulin and musin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.