Anti-Growth Cone monoclonal antibody (DMABT-50824MG)
Mouse anti-Chicken Growth Cone monoclonal antibody for IHC, ELISA, FC, IP, RIA, WB
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Chicken, Mouse, Rat
Embryonic chick tectal membranes
GH receptor; GH-binding protein; GHBP; GHR; GHR_HUMAN; Growth hormone binding protein
A growth cone is a dynamic, actin-supported extension of a developing axon seeking its synaptic target. Their existence was originally proposed by Spanish histologist Santiago Ramón y Cajal based upon stationary images he observed under the microscope. He first described the growth cone based on fixed cells as "a concentration of protoplasm of conical form, endowed with amoeboid movements". Neuronal growth cones are situated on the very tips of nerve cells on structures called axons and dendrites. The sensory, motor, integrative, and adaptive functions of growing axons and dendrites are all contained within this specialized structure.
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Ferrari-Toninelli, G; Bonini, SA; et al. Microtubule stabilizing effect of notch activation in primary cortical neurons. NEUROSCIENCE 154:946-952(2008).
Noda, Y; Niwa, S; et al. Phosphatidylinositol 4-phosphate 5-kinase alpha (PIPK alpha) regulates neuronal microtubule depolymerase kinesin, KIF2A and suppresses elongation of axon branches. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109:1725-1730(2012).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.