Anti-GSTM3 polyclonal antibody

Species Reactivity

Human

Immunogen

A synthetic peptide corresponding to human GSTM3. The sequence is RTQLIRLCYSSDHE

Conjugate

Application Notes

ELISA: 1:4000. & The optimal working dilution should be determined by the end user.

Alternative Names

GSTM3; glutathione S-transferase mu 3 (brain); GST5; GSTB; GTM3; GSTM3-3; glutathione S-transferase Mu 3; hGSTM3-3; brain GST; GST class-mu 3; glutathione S-transferase, Mu-3; glutathione S-aryltransferase M3; glutathione S-alkyltransferase M3; glutathion

Entrez Gene ID

UniProt ID

Antigen Description

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individuals susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants.

Pathway

Biological oxidations; Chemical carcinogenesis; Drug metabolism - cytochrome P450; Glutathione conjugation