Anti-GRIK1 (internal region) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Rat; Human

Immunogen

Synthetic peptide corresponding to 16 internal sequence amino acids of Human GRIK1.

Conjugate

Application Notes

WB: 0.5 - 1 μg/ml; IHC-P: 5 μg/ml.

Alternative Names

GRIK1; glutamate receptor, ionotropic, kainate 1; GLUR5; glutamate receptor, ionotropic kainate 1; GluK1; gluR-5; glutamate receptor 5; excitatory amino acid receptor 3; EAA3; EEA3; GLR5;

Entrez Gene ID

UniProt ID

Antigen Description

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.

Pathway

Activation of Ca-permeable Kainate Receptor; Activation of Kainate Receptors upon glutamate binding; Activation of Na-permeable Kainate Receptors; Glutamatergic synapse; Ionotropic activity of Kainate Receptors; Neuroactive ligand-receptor interaction;