Interacts with the cytoplasmic domain of the epidermal growth factor receptor which is then inhibited. The interaction is mediated by the SH2 domain. Also binds to ERBB2.
Pathway
Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Downstream signal transduction, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; EPHB forward signaling, organism-specific biosystem; GRB7 events in ERBB2 signaling, organism-specific biosystem; Hemostasis, organism-specific biosystem.
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