Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor-regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.
Pathway
ADP signalling through P2Y purinoceptor 12; Activation of GABAB receptors; Adenylate cyclase inhibitory pathway; Axon guidance; CXCR3-mediated signaling events; Calcium Regulation in the Cardiac Cell;
Citations
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