Anti-GNA11 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human GNA11 is used for rabbit immunization.

Conjugate

Alternative Names

GNA11; guanine nucleotide binding protein (G protein), alpha 11 (Gq class); FBH; FBH2; FHH2; HHC2; GNA-11; HYPOC2; guanine nucleotide-binding protein subunit alpha-11; g alpha-11; G-protein subunit alpha-11; guanine nucleotide-binding protein G(y) subunit

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations.

Pathway

ADP signalling through P2Y purinoceptor 1; Amoebiasis; Amoebiasis; Arf6 signaling events; Calcium Regulation in the Cardiac Cell; Calcium signaling pathway; Calcium signaling pathway; Chagas disease (American trypanosomiasis); Cholinergic synapse; Corticotropin-releasing hormone; G Protein Signaling Pathways;