Anti-GLCE monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human GLCE is used for rabbit immunization.

Conjugate

Alternative Names

GLCE; glucuronic acid epimerase; D glucuronyl C5 epimerase , UDP glucuronic acid epimerase; D-glucuronyl C5-epimerase; heparan sulfate epimerase; HSEPI; KIAA0836; glucuronyl C5-epimerase; UDP-glucuronic acid epimerase; heparin/heparan sulfate-glucuronic a

Entrez Gene ID

UniProt ID

Antigen Description

Heparan sulfate (HS) is a negatively charged cell surface polysaccharide required for the biologic activities of circulating extracellular ligands. GLCE is responsible for epimerization of D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) of HS, which endows the nascent polysaccharide chain with the ability to bind growth factors and cytokines (Ghiselli and Agrawal, 2005 [PubMed 15853773]).

Pathway

Glycosaminoglycan biosynthesis - heparan sulfate, organism-specific biosystem; Glycosaminoglycan biosynthesis - heparan sulfate, conserved biosystem; Glycosaminoglycan biosynthesis, heparan sulfate backbone, organism-specific biosystem; Glycosaminoglycan biosynthesis, heparan sulfate backbone, conserved biosystem; Metabolic pathways, organism-specific biosystem; heparan sulfate biosynthesis, organism-specific biosystem; heparan sulfate biosynthesis, conserved biosystem;