Anti-GJB6 (internal region) polyclonal antibody

Species Reactivity

Human

Immunogen

A synthetic peptide corresponding to amino acids at internal region of human GJB6. The sequence is C-RSKRAQTQKNHPNH

Conjugate

Application Notes

ELISA: 1:16000. & The optimal working dilution should be determined by the end user.

Alternative Names

GJB6; gap junction protein, beta 6, 30kDa; ED2; EDH; HED; CX30; HED2; DFNA3; ECTD2; DFNA3B; DFNB1B; gap junction beta-6 protein; connexin 30; connexin-30; gap junction protein, beta 6 (connexin 30); ectodermal dysplasia 2, hidrotic (Clouston syndrome);

Entrez Gene ID

UniProt ID

Antigen Description

Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia.

Pathway

Calcium Regulation in the Cardiac Cell; Gap junction trafficking; Membrane Trafficking.