Anti-GAPDH (aa 126-140) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat; Human; Baboon

Immunogen

Synthetic peptide: DAPMFVMGVNHFKYA, corresponding to amino acids 126-140 of Human GAPDH.

Conjugate

Application Notes

ICC/IF: 5 μg/ml; WB: 0.1 μg/ml.

Alternative Names

GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GAPD; aging-associated gene 9 protein; peptidyl-cysteine S-nitrosylase GAPDH; G3PD; MGC88685;

Entrez Gene ID

UniProt ID

Antigen Description

Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate.

Pathway

Alzheimers disease; Androgen Receptor Signaling Pathway; Gluconeogenesis; Gluconeogenesis, oxaloacetate =>fructose-6P;