Rabbit anti-GAPDH Monoclonal antibody, clone SN225

Antibody Isotype

IgG

Clone

SN225

Immunogen

A peptide corresponding to the C-terminus of GAPDH

Conjugate

Alternative Names

GAPDH; Glyceraldehyde 3-phosphate dehydrogenase; G3PDH; G3PD; GAPD; HEL-S-162eP; actin, cytoplasmic 1; beta cytoskeletal actin; PS1TP5-binding protein 1; glyceraldehyde-3-phosphate dehydrogenase; aging-associated gene 9 protein; peptidyl-cysteine S-nitros

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Pathway

Alzheimer's disease; Alzheimer's Disease; Biosynthesis of amino acids; Carbon metabolism; Disease; Gluconeogenesis; Glucose metabolism; Glycogen storage diseases; Glycolysis; Glycolysis (Embden-Meyerhof pathway); Glycolysis / Gluconeogenesis; Glycolysis and Gluconeogenesis; Glycolysis; HIF-1 signaling pathway; Metabolism; Metabolism of carbohydrates; Myoclonic epilepsy of Lafora; SIDS Susceptibility Pathways; Validated targets of C-MYC transcriptional activation