Anti-GALNT14 monoclonal antibody (DCABH-11670) Made to order

Rabbit anti-Human GALNT14 monoclonal antibody for WB, ELISA

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human GALNT14 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
GALNT14; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14); polypeptide N-acetylgalactosaminyltransferase 14; FLJ12691; GalNac T10; GalNac T14
Entrez Gene ID
UniProt ID

Product Background


Gene summary
GALNT14 (Polypeptide N-Acetylgalactosaminyltransferase 14) is a Protein Coding gene. Among its related pathways are Metabolism and O-linked glycosylation. GO annotations related to this gene include carbohydrate binding and polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT4. This gene encodes a Golgi protein which is a member of the polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-Ts) protein family. These enzymes catalyze the transfer of N-acetyl-D-galactosamine (GalNAc) to the hydroxyl groups on serines and threonines in target peptides. The encoded protein has been shown to transfer GalNAc to large proteins like mucins. Multiple transcript variants encoding different isoforms have been found for this gene.
Antigen Description
GALNT14 (EC 2. 4. 1. 41) belongs to a large subfamily of glycosyltransferases residing in the Golgi apparatus. GALNT enzymes catalyze the first step in the O-glycosylation of mammalian proteins by transferring N-acetyl-D-galactosamine (GalNAc) to peptide substrates. Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney. Polypeptide N-acetylgalactosaminyltransferase 14 is an enzyme that in humans is encoded by the GALNT14 gene. 0The function about GALNT14 antigen include polypeptide N-acetylgalactosaminyltransferase activity; sugar binding; transferase activity, transferring glycosyl groups.
Pathway
Metabolic pathways, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; Mucin type O-Glycan biosynthesis, organism-specific biosystem; Mucin type O-Glycan biosynthesis, conserved biosystem; O-glycan biosynthesis, mucin type core, organism-specific biosystem; O-glycan biosynthesis, mucin type core, conserved biosystem; O-linked glycosylation of mucins, organism-specific biosystem.

Citations


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References


Thorburn, A; Behbakht, K; et al. TRAIL receptor-targeted therapeutics: Resistance mechanisms and strategies to avoid them. DRUG RESISTANCE UPDATES 11:17-24(2008).
Rye, MS; Warrington, NM; et al. Genome-Wide Association Study to Identify the Genetic Determinants of Otitis Media Susceptibility in Childhood. PLOS ONE 7:-(2012).

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