Rabbit Anti-Human GAD1 (internal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to a region derived from internal residues of human glutamate decarboxylase 1 (brain, 67kDa)

Conjugate

Application Notes

WB: 1:200-1:1000

General Notes

This product (Catalog No. DPABH-01957) is a rabbit-derived IgG polyclonal antibody raised against human GAD1. It has been affinity purified by protein A. This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.
DPABH-01957 is suitable for use in Western blot (WB) (1:200–1:1,000) application.
DPABH-01957 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

GAD; SCP; CPSQ1

Entrez Gene ID

UniProt ID