Anti-GABRA5 monoclonal antibody (DCABH-6098)
Rabbit anti-Human GABRA5 monoclonal antibody for WB, ICC/IF
Bring this labeled antibody directly to your bench!
Add to basket
Mouse, Rat, Human
Recombinant fragment within Human GABA A Receptor alpha 5. The exact sequence is proprietary.Database link: P31644
WB: 1/1000 - 1/10000; ICC/IF: 1/50 - 1/100.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
GABRA5; gamma-aminobutyric acid (GABA) A receptor, alpha 5; gamma-aminobutyric acid receptor subunit alpha-5; GABA(A) receptor; alpha 5; GABA(A) receptor, alpha 5
GABRA5 (Gamma-Aminobutyric Acid Type A Receptor Alpha5 Subunit) is a Protein Coding gene. Diseases associated with GABRA5 include childhood absence epilepsy and angelman syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Circadian entrainment. GO annotations related to this gene include receptor activity and chloride channel activity. An important paralog of this gene is GABRA4. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described.
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Gamma-aminobutyric acid (GABA) A receptor, alpha 5, also known as GABRA5, is a protein which in humans is encoded by the GABRA5 gene. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABAA receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABAA receptor. At least 16 distinct subunits of GABAA receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. The function about GABRA5 antigen include GABA-A receptor activity; chloride channel activity; extracellular ligand-gated ion channel activity; ion channel activity; receptor activity; transporter activity.
GABA A receptor activation, organism-specific biosystem; GABA receptor activation, organism-specific biosystem; GABAergic synapse, organism-specific biosystem; GABAergic synapse, conserved biosystem; Ion channel transport, organism-specific biosystem; Ligand-gated ion channel transport, organism-specific biosystem; Morphine addiction, organism-specific biosystem.
Have you cited DCABH-6098 in a publication? Let us know
and earn a reward for your research.
Ma, SC; Abou-Khalil, B; et al. Mutations in GABRA1, GABRA5, GABRG2 and GABRD receptor genes are not a major factor in the pathogenesis of familial focal epilepsy preceded by febrile seizures. NEUROSCIENCE LETTERS 394:74-78(2006).
Bonin, RP; Zurek, AA; et al. Hyperpolarization-Activated Current (I-h) Is Reduced in Hippocampal Neurons from Gabra5-/- Mice. PLOS ONE 8:-(2013).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.