Anti-GABRA5 monoclonal antibody (DCABH-6098)

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Clone
FQS23373
Species Reactivity
Mouse, Rat, Human
Immunogen
Recombinant fragment within Human GABA A Receptor alpha 5. The exact sequence is proprietary.Database link: P31644
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/1000 - 1/10000; ICC/IF: 1/50 - 1/100.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
GABRA5; gamma-aminobutyric acid (GABA) A receptor, alpha 5; gamma-aminobutyric acid receptor subunit alpha-5; GABA(A) receptor; alpha 5; GABA(A) receptor, alpha 5
Entrez Gene ID
UniProt ID

Product Background


Gene summary
GABRA5 (Gamma-Aminobutyric Acid Type A Receptor Alpha5 Subunit) is a Protein Coding gene. Diseases associated with GABRA5 include childhood absence epilepsy and angelman syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Circadian entrainment. GO annotations related to this gene include receptor activity and chloride channel activity. An important paralog of this gene is GABRA4. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described.
Antigen Description
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Gamma-aminobutyric acid (GABA) A receptor, alpha 5, also known as GABRA5, is a protein which in humans is encoded by the GABRA5 gene. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABAA receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABAA receptor. At least 16 distinct subunits of GABAA receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. The function about GABRA5 antigen include GABA-A receptor activity; chloride channel activity; extracellular ligand-gated ion channel activity; ion channel activity; receptor activity; transporter activity.
Pathway
GABA A receptor activation, organism-specific biosystem; GABA receptor activation, organism-specific biosystem; GABAergic synapse, organism-specific biosystem; GABAergic synapse, conserved biosystem; Ion channel transport, organism-specific biosystem; Ligand-gated ion channel transport, organism-specific biosystem; Morphine addiction, organism-specific biosystem.

Citations


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References


Mariotti, V; Melissari, E; et al. Effect of prolonged phenytoin administration on rat brain gene expression assessed by DNA microarrays. EXPERIMENTAL BIOLOGY AND MEDICINE 235:300-310(2010).
Ashley-Koch, AE; Mei, H; et al. An analysis paradigm for investigating multi-locus effects in complex disease: Examination of three GABA(A) receptor subunit genes on 15q11-q13 as risk factors for autistic disorder.. ANNALS OF HUMAN GENETICS 70:281-292(2006).

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