General Notes
This product (Catalog No. DPABH-15437) is a rabbit-derived polyclonal antibody raised against human Furin, targeting the amino acid region 105–221 of the protein. This antibody exhibits cross-reactivity with Human Furin from mouse and rat. It has been affinity purified by Protein A. Furin is a ubiquitous, calcium-dependent serine endoprotease belonging to the proprotein convertase (PC) family, specifically known as PCSK3, that plays a central role in the proteolytic maturation of precursor proteins by cleaving them at multibasic motifs, such as Arg-X-Lys/Arg-Arg↓ or Arg-X-X-Arg↓, primarily within the trans-Golgi network and endosomal compartments of the constitutive secretory pathway. Originally identified and cloned in 1990 from a cDNA library of human liver (HepG2) cells, furin is encoded by a gene on chromosome 15q26.1 and is synthesized as a 794-amino-acid type I transmembrane glycoprotein precursor of approximately 100 kDa.
DPABH-15437 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-15437 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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