Mouse anti-Mouse TLR2 monoclonal antibody for ELISA
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. The function about SPN-E antigen include ATP binding; ATP-dependent RNA helicase activity; RNA helicase activity; RNA-dependent ATPase activity; helicase activity; nucleic acid binding; zinc ion binding.
Flejter, WL; Issa, B; et al. Variegated aneuploidy in two siblings: Phenotype, genotype, CENP-E analysis, and literature review. AMERICAN JOURNAL OF MEDICAL GENETICS 75:45-51(1998).
Fourest-Lieuvin, A; Peris, L; et al. Microtubule regulation in mitosis: Tubulin phosphorylation by the cyclin-dependent kinase Cdk1. MOLECULAR BIOLOGY OF THE CELL 17:1041-1050(2006).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.