Anti-SPN-E monoclonal antibody (CABT-36429RF)

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Clone
AB5204
Species Reactivity
Drosophila
Immunogen
Synthetic peptide derived from residues 1400 to the C terminus of Drosophila melanogaster Spindle E.
Conjugate
Unconjugated

Target


Alternative Names
SPN-E; spindle E; CG3158 gene product from transcript CG3158-RA; CG3158; CG3158-PA; female sterilehomeless
Entrez Gene ID
UniProt ID

Product Background


Antigen Description
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. The function about SPN-E antigen include ATP binding; ATP-dependent RNA helicase activity; RNA helicase activity; RNA-dependent ATPase activity; helicase activity; nucleic acid binding; zinc ion binding.

Citations


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References


Blaukovitsch, M; Halbwedl, I; et al. Sarcomatoid carcinomas of the lung - are these histogenetically heterogeneous tumors?. VIRCHOWS ARCHIV 449:455-461(2006).
Bhargava, R; Dabbs, DJ; et al. Use of immunohistochemistry in diagnosis of breast epithelial lesions. ADVANCES IN ANATOMIC PATHOLOGY 14:93-107(2007).

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