Anti-Filamentous HA monoclonal antibody (DMAB5779)
Mouse anti-Filamentous HA monoclonal antibody for ELISA, WB, IHC
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Whole cell pertussis vaccine + FHA.
FHA; Filamentous hemagglutinin
The filamentous h?magglutinin adhesin (FHA) is a large, filamentous protein that serves as a dominant attachment factor for adherence to host colliery epithelia cells of the respiratory tract. It is associated with biofilm formation and possesses at least four binding domains which can bind to different cell receptors on the epithelial cell surface. One notable bacterium that possess filamentous h?magglutinin adhesin is Bordetella pertussis, which uses this protein as a virulence factor. Filamentous hemagglutinin (FHA) of Bordetella pertussis is a 220 kDa large adhesive surface protein which together with the pertussis toxin (PTx) facilitates attachment of the bacteria to human ciliated cells and macrophages during the course of whooping cough. FHA can recognize and bind the leukocyte-restricted adhesion molecule suggesting that FHA mimics a natural ligand on endothelial cells for this integrin which enables FHA to competitively interfere with CD18-dependent leukocyte migration to the central nervous system. Anti FHA antibodies have been shown to be able to permeabilize the blood-brain barrier.
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Minh, NNT; Edelman, K; et al. Antibody and cell-mediated immune responses to booster immunization with a new acellular pertussis vaccine in school children. VACCINE 16:1604-1610(1998).
Dirix, V; Mielcarek, N; et al. Human dendritic cell maturation and cytokine secretion upon stimulation with Bordetella pertussis filamentous haemagglutinin. MICROBES AND INFECTION 16:562-570(2014).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.