Anti-Filamentous HA monoclonal antibody (DMAB5779)

Mouse anti-Filamentous HA monoclonal antibody for ELISA, WB, IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
IZC 353-02
Species Reactivity
N/A
Immunogen
Whole cell pertussis vaccine + FHA.
Conjugate
Unconjugated

Target


Alternative Names
FHA; Filamentous hemagglutinin

Product Background


Antigen Description
The filamentous h?magglutinin adhesin (FHA) is a large, filamentous protein that serves as a dominant attachment factor for adherence to host colliery epithelia cells of the respiratory tract. It is associated with biofilm formation and possesses at least four binding domains which can bind to different cell receptors on the epithelial cell surface. One notable bacterium that possess filamentous h?magglutinin adhesin is Bordetella pertussis, which uses this protein as a virulence factor. Filamentous hemagglutinin (FHA) of Bordetella pertussis is a 220 kDa large adhesive surface protein which together with the pertussis toxin (PTx) facilitates attachment of the bacteria to human ciliated cells and macrophages during the course of whooping cough. FHA can recognize and bind the leukocyte-restricted adhesion molecule suggesting that FHA mimics a natural ligand on endothelial cells for this integrin which enables FHA to competitively interfere with CD18-dependent leukocyte migration to the central nervous system. Anti FHA antibodies have been shown to be able to permeabilize the blood-brain barrier.

Citations


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References


Berstad, AKH; Holst, J; et al. A nasal whole-cell pertussis vaccine induces specific: systemic and cross-reactive mucosal antibody responses in human volunteers. JOURNAL OF MEDICAL MICROBIOLOGY 49:157-163(2000).
Kosuwon, P; Warachit, B; et al. Reactogenicity and immunogenicity of reduced antigen content diphtheria-tetanus-acellular pertussis vaccine (dTpa) administered as a booster to 4-6 year-old children primed with four doses of whole-cell pertussis vaccine. VACCINE 21:4194-4200(2003).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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