Anti-FBXL4 polyclonal antibody (DPABH-03858)

Rabbit anti-Human FBXL4 (aa 43-351) polyclonal antibody for WB, IHC-P, ICC/IF

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Recombinant fragment corresponding to a region within amino acids 43-351 of Human FbxL4.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/500 - 1/3000; IHC-P: 1/100 - 1/1000; ICC/IF: 1/100 - 1/1000.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
FBXL4; F-box and leucine-rich repeat protein 4; F-box/LRR-repeat protein 4; FBL4; FBL5; F-box protein FBL4
Entrez Gene ID
UniProt ID

Product Background


Gene summary
FBXL4 (F-Box And Leucine-Rich Repeat Protein 4) is a Protein Coding gene. Diseases associated with FBXL4 include mitochondrial dna depletion syndrome 13 and fbxl4-related mitochondrial dna depletion syndrome, encephalomyopathic form. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. An important paralog of this gene is FBXL16. This gene encodes a member of the F-box protein family, which are characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one subunit of modular E3 ubiquitin ligase complexes, called SCF complexes, which function in phosphorylation-dependent ubiquitination. The F-box domain mediates protein-protein interactions and binds directly to S-phase kinase-associated protein 1. In addition to an F-box domain, the encoded protein contains at least 9 tandem leucine-rich repeats. The ubiquitin ligase complex containing the encoded protein may function in cell-cycle control by regulating levels of lysine-specific demethylase 4A. Alternative splicing results in multiple transcript variants.
Antigen Description
FBXL4 (F-box and leucine-rich repeat protein 4) is a protein-coding gene. An important paralog of this gene is FBXL2. Mitochondrial DNA depletion syndrome 13 (MTDPS13) [MIM:615471]: An autosomal recessive disorder characterized by early infantile onset of encephalopathy, hypotonia, lactic acidosis, and severe global developmental delay. Cells derived from patient tissues show defects in mitochondrial oxidative phosphorylation and decreased mtDNA content. Note=The disease is caused by mutations affecting the gene represented in this entry.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Li, Y; Yang, SL; et al. Expression and SNP association analysis of porcine FBXL4 gene. MOLECULAR BIOLOGY REPORTS 37:579-585(2010).

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