Anti-FXYD7 monoclonal antibody (DCABH-11636) Made to order

Rabbit anti-Human FXYD7 monoclonal antibody for WB, ELISA

View other FXYD7 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human FXYD7 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
FXYD7; FXYD domain containing ion transport regulator 7; FXYD domain-containing ion transport regulator 7; FLJ25096
Entrez Gene ID
UniProt ID

Product Background


Gene summary
FXYD7 (FXYD Domain Containing Ion Transport Regulator 7) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Cardiac conduction. GO annotations related to this gene include ion channel activity and sodium channel regulator activity. This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph. D. , sweadner@helix. mgh. harvard. edu. , Dec 2000].
Antigen Description
This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph. D. , sweadner@helix. mgh. harvard. edu. Protein Symbol:P58549-FXYD7_HUMANRecommended name:FXYD domain-containing ion transport regulator 7Protein Accession:P58549The function about FXYD7 antigen include ATPase binding; ion channel activity.

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Sweadner, KJ; Arystarkhova, E; et al. FXYD proteins as regulators of the Na,K-ATPase in the kidney. NA,K-ATPASE AND RELATED CATION PUMPS: STRUCTURE, FUNCTION, AND REGULATORY MECHANISMS 986:382-387(2003).
Li, CM; Grosdidier, A; et al. Structural and functional interaction sites between Na,K-ATPase and FXYD proteins. JOURNAL OF BIOLOGICAL CHEMISTRY 279:38895-38902(2004).

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