This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq]
Pathway
Binding and Uptake of Ligands by Scavenger Receptors; Clathrin derived vesicle budding; Golgi Associated Vesicle Biogenesis; Integrated Pancreatic Cancer Pathway; Iron uptake and transport; Membrane Trafficking; Mineral absorption; Porphyrin and chlorophy
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