Anti-FOXE1 monoclonal antibody (DCABH-11600) Made to order

Rabbit anti-Human FOXE1 monoclonal antibody for WB, ELISA

View other FOXE1 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human FOXE1 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
FOXE1; forkhead box E1 (thyroid transcription factor 2); FKHL15, forkhead box E2 , FOXE2, TITF2; forkhead box protein E1; HFKH4; TTF 2
Entrez Gene ID
UniProt ID

Product Background


Gene summary
FOXE1 (Forkhead Box E1) is a Protein Coding gene. Diseases associated with FOXE1 include bamforth-lazarus syndrome and thyroid cancer, nonmedullary, 4. Among its related pathways are Insulin secretion and TSH signaling pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXE3. This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene functions as a thyroid transcription factor which likely plays a crucial role in thyroid morphogenesis. Mutations in this gene are associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I.
Antigen Description
This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene functions as a thyroid transcription factor which likely plays a crucial role in thyroid morphogenesis. Mutations in this gene are associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I. Bamforth-Lazarus syndrome (BLS) [MIM:241850]: A disease characterized by thyroid agenesis, cleft palate and choanal atresia. Note=The disease is caused by mutations affecting the gene represented in this entry. Forkhead box protein E1 is a protein that in humans is encoded by the FOXE1 gene. The function about FOXE1 antigen include DNA binding; DNA binding, bending; double-stranded DNA binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; transcri.

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Cuesta, I; Zaret, KS; et al. The forkhead factor FoxE1 binds to the thyroperoxidase promoter during thyroid cell differentiation and modifies compacted chromatin structure. MOLECULAR AND CELLULAR BIOLOGY 27:7302-7314(2007).
Kuhnen, P; Turan, S; et al. Identification of PENDRIN (SLC26A4) Mutations in Patients With Congenital Hypothyroidism and "Apparent" Thyroid Dysgenesis. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 99:E169-E176(2014).

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