Synthetic peptide corresponding to Rat FMRP (phospho S499).Database link: Q80WE1
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/1000
Target
Alternative Names
FMR1; fragile X mental retardation 1; FMRP; fragile X mental retardation protein 1 homolog; protein FMR-1; ragile X mental retardation protein; fragile X mental retardation-1 protein; fragile X mental retardation syndrome 1 homolog;
Translation repressor. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).
Pathway
RNA transport;
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Winograd, C; Clayton, D; et al. EXPRESSION OF FRAGILE X MENTAL RETARDATION PROTEIN WITHIN THE VOCAL CONTROL SYSTEM OF DEVELOPING AND ADULT MALE ZEBRA FINCHES. NEUROSCIENCE 157:132-142(2008).
Paribello, C; Tao, L; et al. Open-label add-on treatment trial of minocycline in fragile X syndrome. BMC NEUROLOGY 10:-(2010).
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COA
Certificate of Analysis
