Anti-FMOD monoclonal antibody (DCABH-11589) Made to order

Rabbit anti-Human FMOD monoclonal antibody for WB, ELISA

View other FMOD antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human FMOD is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
FMOD; fibromodulin; fibromodulin proteoglycan; SLRR2E; FM; KSPG fibromodulin
Entrez Gene ID
UniProt ID

Product Background


Gene summary
FMOD (Fibromodulin) is a Protein Coding gene. Diseases associated with FMOD include pseudoachondroplasia and myopia. Among its related pathways are Degradation of the extracellular matrix and Metabolism. An important paralog of this gene is ECM2. Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants.
Antigen Description
Fibromodulin is a member of a family of small interstitial proteoglycans, containing a central region composed of leucine-rich repeats with 4 keratan sulfate chains flanked by disulfide-bonded terminal domains. It may participate in the assembly of the extracellular matrix as it interacts with type I and type II collagen fibrils and inhibits fibrillogenesis in vitro. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity). Fibromodulin is a protein that in humans is encoded by the FMOD gene. Fibromodulin participates in the assembly of the collagen fibers of the extracellular matrix. It binds to the same site on the collagen type I molecule as lumican. It also inhibits fibrillogenesis of collagen type I and collagen type III in vitro. It regulates TGF-beta activities by sequestering TGF-beta into the extracellular matrix.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Sohn, P; Cox, M; et al. Molecular profiling of the developing mouse axial skeleton: a role for Tgfbr2 in the development of the intervertebral disc. BMC DEVELOPMENTAL BIOLOGY 10:-(2010).
Zheng, Z; Nguyen, C; et al. Delayed Wound Closure in Fibromodulin-Deficient Mice Is Associated with Increased TGF-beta 3 Signaling. JOURNAL OF INVESTIGATIVE DERMATOLOGY 131:769-778(2011).

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