Fgr is a member of the Src family of non-receptor tyrosine kinases. It is expressed in neutrophils, monocytes, macrophages and natural killer cells. Expression of Fgr is developmentally regulated and required in normal myelomonocytic differentiation in vivo. HL-60 cells induced to differentiate with retinoic acid express high levels of Fgr.
Pathway
Alpha-synuclein signaling; CXCR4-mediated signaling events; Chemokine signaling pathway; Class I PI3K signaling events; EPHA forward signaling; Ephrin B reverse signaling;
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