Anti-FBXL6 monoclonal antibody (DCABH-11518) Made to order

Rabbit anti-Human FBXL6 monoclonal antibody for WB, ELISA

View other FBXL6 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human FBXL6 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
FBXL6; F-box and leucine-rich repeat protein 6; F-box/LRR-repeat protein 6; FBL6; F-box protein Fbl6; FBL6A
Entrez Gene ID
UniProt ID

Product Background


Gene summary
FBXL6 (F-Box And Leucine-Rich Repeat Protein 6) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity. This gene encodes a member of a family of proteins that are characterized by an F-box motif. The encoded protein also contains leucine-rich repeats. F-box-containing proteins comprise one of the subunits of the SCF (SKP1-cullin-F-box) complex, which functions in phosphorylation-dependent ubiquitination. Alternative splicing results in multiple transcript variants.
Antigen Description
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternative splicing of this gene generates 2 transcript variants. Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The function about FBXL6 antigen include ubiquitin-protein ligase activity.

Citations


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References


Ilyin, GP; Rialland, M; et al. Identification of a novel Skp2-like mammalian protein containing F-box and leucine-rich repeats. FEBS LETTERS 459:75-79(1999).
Schulman, BA; Carrano, AC; et al. Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex. NATURE 408:381-386(2000).

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