FASTK (NP_006703, 67 a.a. ~ 154 a.a) partial recombinant protein with GST tag. The sequence is KWGDRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRRLGQLLG SRPRPPPVEQVTLQDLSQLIIRNCPSFD
Conjugate
Unconjugated
Target
Alternative Names
FASTK; Fas-activated serine/threonine kinase; FAST; fas-activated serine/threonine kinase; FAST kinase;
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined.
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