Anti-FANCM monoclonal antibody (DCABH-11496) Made to order

Rabbit anti-Human FANCM monoclonal antibody for WB, ELISA

View other FANCM antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human FANCM is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
FANCM; Fanconi anemia, complementation group M; KIAA1596; Fanconi anemia group M protein; FAAP250; protein Hef ortholog
Entrez Gene ID
UniProt ID

Product Background


Gene summary
FANCM (Fanconi Anemia Complementation Group M) is a Protein Coding gene. Diseases associated with FANCM include fanconi anemia, complementation group a and fancm-related fanconi anemia. Among its related pathways are DNA Double-Strand Break Repair and Fanconi anemia pathway. GO annotations related to this gene include nucleic acid binding and hydrolase activity. The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M. Alternative splicing results in multiple transcript variants.
Antigen Description
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M. ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions. The function about FANCM antigen include ATP binding; ATP-dependent helicase activity; DNA binding; chromatin binding; helicase activity; hydrolase activity; nuclease activity; nucleotide binding; protein binding.
Pathway
DNA Repair, organism-specific biosystem; FA core complex, organism-specific biosystem; Fanconi Anemia pathway, organism-specific biosystem; Fanconi anemia pathway, conserved biosystem.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Kuo, HK; McMahan, S; et al. Drosophila FANCM Helicase Prevents Spontaneous Mitotic Crossovers Generated by the MUS81 and SLX1 Nucleases. GENETICS 198:935-945(2014).
Mirabello, L; Yu, K; et al. A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma. BMC CANCER 11:-(2011).

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