Anti-FANCB monoclonal antibody (DCABH-11491) Made to order

Rabbit anti-Human FANCB monoclonal antibody for WB, ELISA

View other FANCB antibodies


Host Species
Antibody Isotype
Species Reactivity
A synthetic peptide of human FANCB is used for rabbit immunization.


Alternative Names
FANCB; Fanconi anemia, complementation group B; Fanconi anemia group B protein; FAAP95; FAB; FLJ34064
Entrez Gene ID
UniProt ID

Product Background

Gene summary
FANCB (Fanconi Anemia Complementation Group B) is a Protein Coding gene. Diseases associated with FANCB include fanconi anemia, complementation group b and fanconi anemia, complementation group a. Among its related pathways are DNA Double-Strand Break Repair and Fanconi anemia pathway. This gene encodes a member of the Fanconi anemia complementation group B. This protein is assembled into a nucleoprotein complex that is involved in the repair of DNA lesions. Mutations in this gene can cause chromosome instability and VACTERL syndrome with hydrocephalus.
Antigen Description
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group B. Alternative splicing results in two transcript variants encoding the same protein. Fanconi anemia complementation group B (FANCB) [MIM:300514]: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. Some severe FANCB cases manifest features of VACTERL syndrome with hydrocephalus. Note=The disease is caused by mutations affecting the gene represented in this entry. Fanconi anemia group B protein is a protein that in humans is encoded by the FANCB gene.
DNA Repair, organism-specific biosystem; FA core complex, organism-specific biosystem; Fanconi Anemia pathway, organism-specific biosystem; Fanconi anemia pathway, conserved biosystem.


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Rajendra, E; Oestergaard, VH; et al. The Genetic and Biochemical Basis of FANCD2 Monoubiquitination. MOLECULAR CELL 54:858-869(2014).
Garcia, MJ; Fernandez, V; et al. Analysis of FANCB and FANCN/PALB2 Fanconi Anemia genes in BRCA1/2-negative Spanish breast cancer families. BREAST CANCER RESEARCH AND TREATMENT 113:545-551(2009).

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