General Notes
This product (Catalog No. DPABH-11179) is a rabbit-derived polyclonal antibody raised against human Egr1, targeting the amino acid region 282–433 of the protein. This antibody exhibits cross-reactivity with Human Egr1 from mouse and rat. It has been affinity purified by Protein A. Early Growth Response 1 (EGR1) is a zinc finger transcription factor encoded by the EGR1 gene located on the long arm of human chromosome 5 at position 5q31.2, consisting of a nuclear protein that functions as a DNA-binding regulator of transcription. As an immediate early gene, EGR1 is rapidly induced in response to diverse extracellular stimuli such as growth factors, cytokines, and stress signals, primarily through the mitogen-activated protein kinase (MAPK) pathway, enabling it to orchestrate cellular adaptations in proliferation, differentiation, and survival. The protein features three C2H2-type zinc finger domains that facilitate specific binding to GC-rich DNA sequences in target gene promoters, thereby activating or repressing transcription of genes involved in critical biological processes.
DPABH-11179 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-11179 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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