Anti-EYA4 monoclonal antibody (DCABH-11471) Made to order

Rabbit anti-Human EYA4 monoclonal antibody for WB, ELISA

View other EYA4 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human EYA4 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
EYA4; eyes absent homolog 4 (Drosophila); CMD1J, DFNA10, eyes absent (Drosophila) homolog 4; eyes absent homolog 4; dJ78N10.1 (eyes absent); CMD1J
Entrez Gene ID
UniProt ID

Product Background


Gene summary
EYA4 (EYA Transcriptional Coactivator And Phosphatase 4) is a Protein Coding gene. Diseases associated with EYA4 include deafness, autosomal dominant 10 and cardiomyopathy, dilated, 1j. Among its related pathways are DNA Double-Strand Break Repair and DNA Double Strand Break Response. GO annotations related to this gene include protein tyrosine phosphatase activity. An important paralog of this gene is EYA1. This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant non-syndromic sensorineural 10 locus. The encoded protein is also a putative oncogene that mediates DNA repair, apoptosis, and innate immunity following DNA damage, cellular damage, and viral attack. Defects in this gene are also associated with dilated cardiomyopathy 1J. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Antigen Description
This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant nonsyndromic sensorineural 10 locus. Defects in this gene are also associated with dilated cardiomyopathy 1J. Three transcript variants encoding distinct isoforms have been identified for this gene. Cardiomyopathy, dilated 1J (CMD1J) [MIM:605362]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. CMD1J is characterized by the association of sensorineural hearing loss and dilated cardiomyopathy in the absence of other anomalies. Note=The disease is caused by mutations affecting the gene represented in this entry. Deafness, autosomal dominant, 10 (DFNA10) [MIM:601316]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Eyes absent homolog 4 is a protein that in humans is encoded by the EYA4 gene. 0The function about EYA4 antigen include hydrolase activity; metal ion binding; protein tyrosine phosphatase activity.

Citations


Have you cited DCABH-11471 in a publication? Let us know and earn a reward for your research.

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

Customer Reviews


Write a review, share your experiences with others and get rewarded !
Product Name Cat. No. Applications Host Species Datasheet Price Add to Basket

References


Rye, MS; Bhutta, MF; et al. Unraveling the genetics of otitis media: from mouse to human and back again. MAMMALIAN GENOME 22:66-82(2011).
Osborn, NK; Zou, HZ; et al. Aberrant methylation of the eyes absent 4 gene in ulcerative colitis-associated dysplasia. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY 4:212-218(2006).

Online Inquiry

Name:
Phone: *
E-mail Address: *
Service & Products Interested: *
Project Description:
Verification Code: * Please input "diagnostics" as verification code.

Online Inquiry

  Interested in larger quantities ? request a quote!
  Protocol may be improved. Please feel free to contact us to obtain the latest version.!

Ordering Information

Payment methods we support:
Invoice / Purchase Order
Credit card

OUR PROMISE TO YOU Guaranteed product quality expert customer support

Inquiry Basket