Anti-EXOG monoclonal antibody (DMABT-H16281)


Host Species
Antibody Isotype
Species Reactivity
ENDOGL1 partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.


Alternative Names
EXOG; endo/exonuclease (5-3), endonuclease G-like; ENDOGL1, ENDOGL2, endonuclease G like2, endonuclease G like 2; nuclease EXOG, mitochondrial; ENGL; ENGL a
Entrez Gene ID
UniProt ID

Product Background

Gene summary
EXOG (Endo/Exonuclease (5-3), Endonuclease G-Like) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and endonuclease activity. An important paralog of this gene is ENDOG. This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18.
Antigen Description
Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5-3 exonuclease activity. The function about EXOG antigen include endonuclease activity; hydrolase activity; metal ion binding; nucleic acid binding.


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Tann, AW; Boldogh, I; et al. Apoptosis Induced by Persistent Single-strand Breaks in Mitochondrial Genome CRITICAL ROLE OF EXOG (5 '-EXO/ENDONUCLEASE) IN THEIR REPAIR. JOURNAL OF BIOLOGICAL CHEMISTRY 286:31975-31983(2011).
Scibior, A; Zaporowska, H; et al. Lipid peroxidation in the kidney of rats treated with V and/or Mg in drinking water. JOURNAL OF APPLIED TOXICOLOGY 30:487-496(2010).

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