Anti-EXOC4 monoclonal antibody, clone 5G2

Antibody Isotype

IgG2a

Clone

5G2

Species Reactivity

Human; Mouse; Rat

Immunogen

EXOC4 (NP_068579, 1 a.a. ~ 109 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

EXOC4; exocyst complex component 4; SEC8 like 1 (S. cerevisiae) , SEC8L1; KIAA1699; MGC27170; REC8; SEC8; Sec8p; SEC8-like 1; exocyst complex component Sec8; SEC8L1;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Pathway

Arf6 trafficking events, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; Insulin Pathway, organism-specific biosystem; Insulin Synthesis and Processing, organism-specific biosystem; Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem; Tight junction, organism-specific biosystem.