Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.
Pathway
Eukaryotic Translation Termination; Metabolism of proteins; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation
Citations
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