Anti-ESRRB polyclonal antibody (DPABH-20661)

Rabbit anti-Human ESRRB (aa 38-87) polyclonal antibody for WB Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Synthetic peptide corresponding to a region within N terminal amino acids 38-87 (SSDASGGFGL ALGTHANGLD SPPMFAGAGL GGTPCRKSYE DCASGIMEDS) of Human Estrogen Related Receptor beta (NP_004443)
Conjugate
Unconjugated

Applications


Application Notes
WB: 1 μg/ml.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
ESRRB; estrogen-related receptor beta; ERR2; ERRb; ESRL2; NR3B2
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ESRRB (Estrogen Related Receptor Beta) is a Protein Coding gene. Diseases associated with ESRRB include deafness, autosomal recessive 35 and dfnb35 nonsyndromic hearing loss and deafness. Among its related pathways are Gene Expression and Signaling pathways regulating pluripotency of stem cells. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is AR. This gene encodes a protein with similarity to the estrogen receptor. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development.
Antigen Description
Nuclear receptor, may regulate ESR1 transcriptional activity. Deafness, autosomal recessive, 35 (DFNB35) [MIM:608565]: A form of non-syndromic deafness characterized by non-progressive, prelingual hearing loss. Note=The disease is caused by mutations affecting the gene represented in this entry. Estrogen-related receptor beta (ERR-β), also known as NR3B2 (nuclear receptor subfamily 3, group B, member 2), is a nuclear receptor that in humans is encoded by the ESRRB (EStrogen Related Receptor Beta) gene. This gene encodes a protein with sequence similarity to the estrogen receptor, a member of nuclear hormone receptor family of steroid hormone receptors. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development. The function about ESRRB antigen include RNA polymerase II distal enhancer sequence-specific DNA binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; sequence-specific DNA binding; steroid binding.
Pathway
Gene Expression; Nuclear Receptor transcription pathway; Wnt Signaling Pathway and Pluripotency.

Citations


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References


Bombail, V; MacPherson, S; et al. Estrogen receptor related beta is expressed in human endometrium throughout the normal menstrual cycle. HUMAN REPRODUCTION 23:2782-2790(2008).
Ficz, G; Branco, MR; et al. Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation. NATURE 473:398-U589(2011).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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