ESRRB (Estrogen Related Receptor Beta) is a Protein Coding gene. Diseases associated with ESRRB include deafness, autosomal recessive 35 and dfnb35 nonsyndromic hearing loss and deafness. Among its related pathways are Gene Expression and Signaling pathways regulating pluripotency of stem cells. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is AR. This gene encodes a protein with similarity to the estrogen receptor. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development.
Nuclear receptor, may regulate ESR1 transcriptional activity. Deafness, autosomal recessive, 35 (DFNB35) [MIM:608565]: A form of non-syndromic deafness characterized by non-progressive, prelingual hearing loss. Note=The disease is caused by mutations affecting the gene represented in this entry. Estrogen-related receptor beta (ERR-β), also known as NR3B2 (nuclear receptor subfamily 3, group B, member 2), is a nuclear receptor that in humans is encoded by the ESRRB (EStrogen Related Receptor Beta) gene. This gene encodes a protein with sequence similarity to the estrogen receptor, a member of nuclear hormone receptor family of steroid hormone receptors. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development. The function about ESRRB antigen include RNA polymerase II distal enhancer sequence-specific DNA binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; sequence-specific DNA binding; steroid binding.