Specifications
Species Reactivity
Mouse; Human
Immunogen
Recombinant fragment, corresponding to amino acids 559-976 of Human Eph receptor A2 (NP_004422).
Applications
Application Notes
WB: 1/500 - 1/2000; IHC-P: 5 μg/ml;
Target
Alternative Names
EPHA2; EPH receptor A2; ECK, EphA2; ephrin type-A receptor 2; soluble EPHA2 variant 1; tyrosine-protein kinase receptor ECK; epithelial cell receptor protein tyrosine kinase; ECK; CTPA; ARCC2; CTPP1;
Product Background
Antigen Description
Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 and -A5. Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). Induces apoptosis in a p53/TP53-independent, caspase-8-dependent manner.
Pathway
Arf6 signaling events, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Direct p53 effectors, organism-specific biosystem; EPHA forward signaling, organism-specific biosystem; EPHA2 forward signaling, organism-specific biosystem; EphrinA-EPHA pathway, organism-specific biosystem.
Citations
Publication ()
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COA
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