Anti-ENPP1 monoclonal antibody (DCABH-11412) Made to order

Rabbit anti-Human ENPP1 monoclonal antibody for WB, ELISA

View other ENPP1 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human ENPP1 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase 1; M6S1, NPPS, PDNP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1; PC 1; PCA1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ENPP1 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 1) is a Protein Coding gene. Diseases associated with ENPP1 include cole disease and hypophosphatemic rickets, autosomal recessive, 2. Among its related pathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include nucleic acid binding and protein homodimerization activity. An important paralog of this gene is ENPP3. This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance.
Pathway
Endochondral Ossification, organism-specific biosystem; Insulin Signaling, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of vitamins and cofactors, organism-specific biosystem; Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem; Nicotinate and nicotinamide metabolism, organism-specific biosystem.

Citations


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References


Keshavarz, P; Inoue, H; et al. No evidence for association of the ENPP1 (PC-1) K121Q variant with risk of type 2 diabetes in a Japanese population (vol 51, pg 559, 2006). JOURNAL OF HUMAN GENETICS 51:644-644(2006).
Weedon, MN; Shields, B; et al. No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 UK caucasians. DIABETES 55:3175-3179(2006).

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